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A total of 17 years after its introduction, bupropion has become a commonly used antidepressant, suitable for first-line use.

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in studies conducted in rats and rabbits, bupropion was administered orally during the period of organogenesis at doses of up to 450 and 150 mg per kg per day, respectively approximately 11 and 7 times the mrhd, respectively, on a mg per m basis .

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although there are no independent trials demonstrating the antidepressant effectiveness of wellbutrin xl, studies have demonstrated similar bioavailability of wellbutrin xl to both the immediate-release formulation and to the sustained-release formulation of bupropion under steady-state conditions, i.

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18 its use in those taking potent cyp2d6 inhibitors such as fluoxetine, paroxetine, sertraline, duloxetine, bupropion, and quinidine is recommended against due to the potential for its accumulation in the absence of full cyp2d6 catalytic activity.

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